The benefits of Renin Angiotensin Aldosterone System Inhibitors (RAASi) in cardio-renal protection are well-established, and as such their use is recommended by both heart failure1–3 and chronic kidney disease (CKD)4 association guidelines. These guidelines recommend the highest-tolerated targeted doses of RAASi in order to replicate the positive clinical outcomes from…
Chronic kidney disease causes progressive loss of mineral homeostasis and a continuum of comorbidities and complications. Chronic kidney disease-mineral bone disorder (CKD-MBD) describes the broader clinical syndrome encompassing mineral homeostasis, vascular calcification and bone disorders1. This downloadable presentation describes how calcium and phosphate levels are normally maintained in the body…
The use of oral iron to correct iron deficiency and treat anaemia is associated with issues of compliance, gastrointestinal side-effects, non-response and variations in bioavailability between patients.1,2 However, as a simple and inexpensive option, it enjoys widespread use in non-dialysis dependent chronic kidney disease patients (ND-CKD). In an open-access paper,…
Potassium is critical for many physiological functions. Although normal homeostatic mechanisms precisely maintain the serum potassium level within a narrow range, pathogenic disturbances can lead to hyperkalaemia, a relatively common clinical condition that can induce potentially fatal cardiac arrhythmias. Understanding the pathophysiology of hyperkalaemia is the focus of this e-learning…
In this article, the COMPACT RENAL team provides a summary of key presentations from American Society of Nephrology Kidney Week 2017 relating to CKD-MBD, including real-world evidence on the phosphate binder sucroferric oxyhydroxide. KDIGO update An update to the KDIGO CKD-MBD guidelines was published earlier this year, in response to…
At the American Society of Nephrology’s Kidney Week 2017 congress in New Orleans, results from several studies looking at the prevalence and impact of hyperkalemia were presented, alongside data for new therapies which may allow greater use of renin-angiotensin aldosterone system inhibition (RAASi) in patients with CKD and cardiac disease….
The American Society of Nephrology (ASN) Kidney Week 2017 was held in New Orleans in early November 2017. Presentations related to iron deficiency and anaemia provided updates on both benefits and risks with current available therapies. Presenters also discussed treatments under development, particularly those that focus on activating the Hypoxia-Inducible…
This week New Orleans will host the ASN Kidney Week Congress. In preparation for this year’s meeting, the COMPACT RENAL team has summarised key sessions and posters relating to iron deficiency and anaemia. Note that hyperlinks to symposia will take you to the ASN Kidney Week website, where you will…
The American Society of Nephrology – Kidney Week 2017 (ASN 2017) congress takes place October 31st to November 5th 2017 in New Orleans. In this article, the COMPACT RENAL team has highlighted key sessions and posters relating to hyperkalemia. Note that hyperlinks to symposia will take you to the ASN…
The ASN 2017 Kidney Week Congress starts this week in New Orleans. In this article, the COMPACT RENAL team has highlighted key sessions and posters relating to CKD-MBD. Note that hyperlinks to symposia will take you to the ASN Kidney Week website, where you will have the option to add…
Balancing phosphate levels and protein intake in dialysis dependent CKD patients is a significant challenge.[1] Impaired renal phosphate excretion and high protein dietary requirements frequently lead to hyperphosphatemia, which negatively impacts patients’ mineral bone health.[2] The growing elderly dialysis population is particularly challenging to manage due to its additional nutritional…
Vitamin D metabolism is central to the endocrine regulation of calcium and phosphorus homeostasis and its deficiency can result in serious morbidity including secondary hyperparathyroidism and fractures[1]. This downloadable presentation summarises the consequence of vitamin D insufficiency, discusses the vitamin D levels we should be targeting in our patients with…
