News & Views

ASN 2014 (Part 4): Feasibility of clinical trials involving serum P targets higher than suggested by current guidelines

In this video from the ASN Kidney Week Congress, Dr Ramya Bhargava discusses results from a multicentre study that assessed the feasibility of conducting a trial regarding serum phosphorus (P) levels and clinical outcomes, including mortality. The goal of this study was to establish whether it would be possible to…

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Date of publication:
January 26, 2015

News & Views

ERA-EDTA (Part 6) – Variability in CKD-MBD parameters is associated with a greater risk of hospitalization

In the last in our video series from the ERA-EDTA 2014 Congress, Professor Fellype Barreto from Brazil discusses results from an analysis of the MONDO observational study, which examined the association between mineral metabolism parameter variation and hospitalizations. The results were presented in an oral abstract at the ERA-EDTA Congress….

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Date of publication:
September 9, 2014

News & Views

Might inconsistencies in associations between serum phosphorus levels and mortality risk in CKD be partly explained by fasting status?

Variations in the approach to measuring serum phosphorus may partly explain the heterogeneity in results of previous studies investigating the association between serum phosphorus and mortality, according to data presented at ASN Kidney Week 2013. Alex Chang and Morgan Grams of Johns Hopkins University analyzed data from the NHANES III…

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Date of publication:
December 20, 2013

News & Views

COSMOS: use of phosphate-binding agents is associated with a lower risk of mortality

Treatment with phosphate-binding therapy was associated with a lower all-cause and cardiovascular mortality risk in the European COSMOS observational study of hemodialysis patients. Cannata-Andía et al. studied [1] almost 6,800 patients from 227 dialysis centers in 20 European countries over a three-year period. 85% of patients were prescribed phosphate binders,…

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Date of publication:
August 8, 2013

News & Views

ERA-EDTA 2013: is phosphate a risk factor for cardiovascular disease beyond CKD?

Is phosphate a risk factor for cardiovascular disease beyond CKD? This was the question posed during a well-attended afternoon symposium at the recent ERA-EDTA 2013 Congress. In patients with CKD, it is widely recognized that an elevated serum phosphorus level is a risk (1) factor (2) for cardiovascular and all-cause…

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Professor Angel de Francisco
Expert article by:
Professor Angel de Francisco

Date of publication:
June 25, 2013

News & Views

ERA-EDTA 2013: COSMOS strengthens our understanding of the relationship between bone mineral parameters and mortality risk

In the first of our series covering presentations on CKD-MBD at the 2013 ERA-EDTA Congress, we focus on mortality risk in dialysis patients, considering the relationship of both serum phosphorus levels and phosphate binder prescription with patient survival. The COSMOS study [1] of over 6,000 European hemodialysis patients promises to…

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Date of publication:
June 11, 2013

News & Views

Preview of ERA-EDTA Congress 2013: phosphorous as a cardiovascular risk factor and continuing to assess the impact of EVOLVE

The 2013 ERA-EDTA Congress in Istanbul starts this coming weekend, and the CKD-MBD agenda includes multiple sessions and posters that focus on clinical outcomes related to serum phosphorous levels and phosphate-binding therapies. Mortality risk in CKD-MBD Three oral presentations focus on survival outcomes resulting from CKD-MBD therapies: On Monday afternoon,…

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Date of publication:
May 16, 2013

News & Views

Does phosphate binder treatment confer a survival benefit on treated patients? (Part II)

Until recently, evidence has been lacking that directly associates phosphate binder treatment with reduced mortality. In Part 1 of our article, we examined several recent studies that have investigated this association. Two studies [1] [2] in particular have shown mortality reductions of 25% associated with phosphate binder use. However, these and…

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Date of publication:
June 1, 2012

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