Date of publication: January 16, 2018

Medical Education

Understanding CKD-MBD: Pathophysiology, Burden and Clinical Consequences

Chronic kidney disease causes progressive loss of mineral homeostasis and a continuum of comorbidities and complications. Chronic kidney disease-mineral bone disorder (CKD-MBD) describes the broader clinical syndrome encompassing mineral homeostasis, vascular calcification and bone disorders1. This downloadable presentation describes how calcium and phosphate levels are normally maintained in the body and what goes wrong in CKD. In addition, it provides an introduction to the roles PTH, vitamin D and FGF23 play in the development of bone and cardiovascular abnormalities, and their association with mortality risk.

This presentation was developed by the COMPACT RENAL editorial team in association with Dr Pablo Antonio Ureña Torres (Nephrologist at Clinique du Landy, Service de Néphrologie-Dialyse, Saint Ouen, and Consultant, Service des Explorations Fonctionnelles, Necker-Enfant Malades Hospital, Paris, France).


  1. KDIGO CKD-MBD Work Group. Kidney Int 2009;76:S1–130.

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  • Very nice presentation of the pathophysiology of CKD-MBD! This presentation should be shown also or even more to Non-Nephrologists since they need to know that cv risk for patients with kidney disease begins early on (eGFR< 70 ml/min) and that holding the phosphate homeostasis by malcompensation (increasingly FGF-23) is one main reason for cv end organ damage. So keeping phosphate down (to low normal levels) is the mainstay of preventional therapy. In order to avoid a high dietary phosphate load it is necessary that the food industry quantifies the phosphate additives in processed food items.


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