Date of publication: January 16, 2018

Medical Education

Understanding CKD-MBD: Pathophysiology, Burden and Clinical Consequences

Chronic kidney disease causes progressive loss of mineral homeostasis and a continuum of comorbidities and complications. Chronic kidney disease-mineral bone disorder (CKD-MBD) describes the broader clinical syndrome encompassing mineral homeostasis, vascular calcification and bone disorders1. This downloadable presentation describes how calcium and phosphate levels are normally maintained in the body and what goes wrong in CKD. In addition, it provides an introduction to the roles PTH, vitamin D and FGF23 play in the development of bone and cardiovascular abnormalities, and their association with mortality risk.

This presentation was developed by the COMPACT RENAL editorial team in association with Dr Pablo Antonio Ureña Torres (Nephrologist at Clinique du Landy, Service de Néphrologie-Dialyse, Saint Ouen, and Consultant, Service des Explorations Fonctionnelles, Necker-Enfant Malades Hospital, Paris, France).

REFERENCES

  1. KDIGO CKD-MBD Work Group. Kidney Int 2009;76:S1–130.

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