Date of publication: May 22, 2016

Presentation Resources

KDIGO Highlights – NEW Speaker’s Guide on Iron Management

The 2014 KDIGO Controversies Conference addressed key issues related to iron management in CKD. This downloadable speaker’s guide summarizes key information and conclusions from the conference on: (1) Iron deficiency vs. overload, (2) Oxidative Stress, (3) Infection Risk and (4) Hypersensitivity.

 

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Comments

  • it is a very good revision, allowed a better use of iron to patients

  • Interesting…but still confused about the infection Risk and The use of IV Iron? … Is it due to the invasive pathway to give iron or due to iron itself?

    • Thank you for your comment.

      We assume that by “invasive pathway” that you are referring to venipuncture, which always carries an infection risk. This is particularly relevant in non-dialysis CKD patients as vessel preservation is important; newer iron agents may have an advantage in terms of reducing venipuncture. For hemodialysis patients, the IV iron is almost always given through the dialysis circuit.

      Regarding any increased infection risk related to the iron itself, the KDIGO guide highlights that there is conflicting evidence on this topic from observational studies. Multiple studies have focused on the potential association between serum ferritin levels and infection rates, but at usual IV iron doses(<400mg/month) there is no proven link between IV iron usage and increased infection risk.

      Please note: IV iron must be used with caution in cases of acute or chronic infection. Please check the relevant product label before administration.

      References:
      1. Macdougall IC, Bircher AJ, Eckardt K-U, et al. Iron management in chronic kidney disease: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference. Kidney Int. 2016;89:28-39.
      2. Ishida et al. SeminDial. 2014;27:26–36.

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