Iron deficiency/iron deficiency-anaemia (ID/IDA) is a common co-morbidity of chronic kidney disease (CKD)[1,2] and, if left untreated, can worsen the outcome of patients who already have compromised renal function. We also now know that ID is not a single condition, but comprise multiple ID syndromes, with or without anaemia, which can even co-exist in a single patient. Understanding the differences between ID syndromes will enable better clinical diagnosis that will facilitate the most appropriate treatment.
This e-learning module was developed with scientific input and guidance from Professor Carlo Gaillard (Chair of Nephrology at the University Medical Centre, Groningen, The Netherlands). The module is available in a user-friendly interactive presentation format that is divided over three chapters to enable you to learn at your own pace and gain maximum benefit from the information presented.
Chapter 1 reviews the prevalence of ID in patients with CKD and highlights the non-haematological consequence of ID. In addition, you will learn about the symptoms of ID and the two most relevant patho-mechanisms associated with the disorder. Chapter 2 introduces the concept of absolute and functional ID, and explores their different etiologies. Chapter 3 provides a summary of the most commonly used diagnostic markers for ID/IDA, including advantages and limitations, and recommended definitions and thresholds.
Interactive question-and-answer sections at the end of each chapter will evaluate your learning and improve your understanding of the pathophysiology of ID.
- Macdougall IC, Horl WH, Jacobs C, et al. European best practice guidelines 6-8: assessing and optimizing iron stores. Nephrol Dial Transplant 2000;15 Suppl 4:20–32.
- Fishbane S, Pollack S, Feldman HI, et al. Iron indices in chronic kidney disease in the National Health and Nutritional Examination Survey 1988-2004. Clin J Am Soc Nephrol 2009;4:57–61.
- Krikorian S, Shafai G, Shamim K. Managing iron deficiency anemia of CKD With IV iron. US Pharmacist 2013;38:22–26.
- Goodnough LT. Iron deficiency syndromes and iron-restricted erythropoiesis (CME). Transfusion 2012;52:1584–1592.