News & Views

ERA-EDTA 2016: Latest insights on the safety of IV iron therapy

The 53rd ERA-EDTA Congress was held in Vienna this year, with an extensive program covering a range of topics relevant to its international nephrology audience. This summary provides highlights of the sessions on iron deficiency anemia in CKD patients. FIND-CKD study: The latest safety data Dr Simon Roger presented 1-year…

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Date of publication:
July 6, 2016

News & Views

ERA-EDTA 2016: The Burden of Hyperkalemia

The 2016 ERA-EDTA Congress featured two satellite symposia that highlighted the disease burden of hyperkalemia, as well as an oral session on mineral metabolism that discussed new potassium binder therapies (that are not approved at the time of writing in Europe). Two satellite symposia included presentations on the challenges associated…

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Date of publication:
June 23, 2016

News & Views

ERA-EDTA 2016: CKD-MBD Management and Associated Outcomes

The ERA-EDTA 2016 congress was held last month in Vienna, Austria. Here is COMPACT RENAL’s round-up of the highlights in CKD-MBD. Non-calcium phosphate binders and reduced mortality Non-calcium phosphate binders reduce calcium loading in dialysis patients and may reduce risk of death compared with calcium-based phosphate binders, but it is…

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Date of publication:
June 17, 2016

News & Views

Proactive IV Iron Therapy in Haemodialysis Patients: The PIVOTAL Trial

As highlighted by the recently published KDIGO Controversies Conference findings, questions remain regarding the benefits and safety of IV iron use in patients with chronic kidney disease (CKD). An ongoing study which hopes to provide many of the answers is the “groundbreaking” PIVOTAL Trial.[1] Led by Dr Iain Macdougall, Professor…

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Date of publication:
May 19, 2016

News & Views

Highlights from the FIND-CKD Study

The FIND-CKD study results reported by Iain Macdougall and colleagues provide much needed information on the effects of IV iron therapy in non-dialysis-dependent chronic kidney disease patients.[1] 626 patients from 20 countries met the inclusion criteria, which included: CKD Stage 3-5ND Relatively stable eGFR decline No exposure to ESA therapy…

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Date of publication:
May 19, 2016

News & Views

Practice Guidelines for Iron Deficiency and Anemia in CKD

Iron deficiency anemia is common in patients with chronic kidney disease (CKD). As kidney function declines, the incidence and prevalence of anemia increases, particularly in patients with more advanced CKD. Anemia occurs due to loss of functional kidney mass and can be worsened by gastrointestinal bleeding, hemodialysis, frequent blood sampling,…

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Date of publication:
May 19, 2016

News & Views

Hyperkalemia in Chronic Disease: Balancing Medication Benefits and Risks

Potassium has several physiological roles including maintenance of the resting membrane action potential, particularly of the myocardium. Because 98% of potassium is stored intracellularly, homeostasis of the extracellular 2% is essential, and leads to a narrow normal range of 3.5-5 mmol/l. An upset in this balance resulting in hyperkalemia can…

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Date of publication:
May 19, 2016

Medical Education

Pathophysiology of Hyperphosphatemia

Loss of renal function can lead to reduced phosphate excretion, phosphate dysregulation and, over time, vascular calcification. This downloadable presentation summarizes the pathophysiology of phosphate dysregulation in CKD and examines the mechanisms by which vascular calcification may occur.

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Date of publication:
May 19, 2016

News & Views

Hyperkalemia in Chronic Disease

Potassium is the most abundant cation in the body, essential for maintaining fluid and electrolyte balance. 98% of potassium is stored in the intracellular space, with only 2% extracellularly.[1] However, this 2% is vital for maintaining the intracellular and extracellular ratio of potassium, and therefore the resting membrane potential, particularly…

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Date of publication:
May 19, 2016

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